Applied Research Scientist, Cryo-Electron Microscopy and Tomography

Overview

InstaDeep, founded in 2014, is a pioneering AI company at the forefront of innovation. With strategic offices in major cities worldwide, including London, Paris, Berlin, Tunis, Lagos, Cape Town, Boston, and San Francisco, InstaDeep collaborates with giants like Google DeepMind and prestigious educational institutions like MIT, Stanford, Oxford, UCL, and Imperial College London. We are a Google Cloud Partner and a select NVIDIA Elite Service Delivery Partner. We have been listed among notable players in AI, fast-growing companies, and Europe’s 1000 fastest-growing companies in 2022 by Statista and the Financial Times. Our recent acquisition by BioNTech has further solidified our commitment to leading the industry.

Join us to be a part of the AI revolution!

InstaDeep is looking for a Research Scientist to join our team working at the intersection of machine learning (ML) and cryo-electron microscopy and tomography (Cryo-EM/ET). The determination and study of 3D molecular structures… can offer fundamental insights into the mechanisms that govern most cellular functions. In this regard Cryo-EM and ET are powerful tools for determining high-resolution structures of biomolecules in near native state. As these imaging techniques generate significant raw data, machine learning has great potential to accelerate and improve many stages of the processing pipeline; from particle picking and annotation, to reconstruction of 3D electron density maps from 2D images, modelling conformal heterogeneity of the imaged particles and, ultimately, generating atomistic structures with angstrom-level resolution.

As a Research Scientist, you will collaborate with other members of the BioAI and Research departments, as well as strategic partners such as BioNTech, to advance our understanding of structural biology with ML. You will bring experience Cryo-EM and ET and play a key role in both developing fundamental research and bringing these technologies to real-world applications.

Responsibilities
• Collaborate within in-house and external experts in computational and structural biology, and machine-learning, to implement, develop and test new technologies.
• Use established tools and databases to build, explore and analyse biological datasets and systems
• Contribute to the design and implementation of models, tools and libraries to accelerate our research efforts.
• Report and present experimental results and research findings clearly and effectively, both internally and externally, verbally and in writing.
• Contribute to the team’s publication efforts.

Requirements
• M.S./PhD in Computational Biology, Machine Learning or a related scientific field.
• Experience with structure resolution in cryo-EM or ET.
• Proficient in writing clean and maintainable code in Python.
• Excellent communication skills and collaborative spirit.

Desirables
• Individuals in this role are expected to be accomplished in computational biology or machine learning.
• Experience using a deep learning frameworks like PyTorch, Tensorflow and/or Jax.
• Experience with any of the following biological topics would be a plus; Cryo-EM/ET data analysis: denoising, filtering, segmentation; Experience working with large biological datasets, databases (EMPIAR, PDB, Uniprot, etc.) and their API technologies; Molecular dynamics; Structural biology
• Demonstrated ability to contribute to novel research efforts; such as publications at leading life science or ML venues.

Our commitment to our people

We empower individuals to celebrate their uniqueness here at InstaDeep. Our team comes from all walks of life, and we’re proud to continue encouraging and supporting applicants from underrepresented groups across the globe. Our commitment to creating an authentic environment comes from our ability to learn and grow from our diversity, and how better to experience this than by joining our team? We operate on a hybrid work model with guidance to work at the office at least 2 to 3 days per week to encourage close collaboration and innovation. We are continuing to review the situation with the well-being of InstaDeepers at the forefront of our minds.

Right to work: Please note that you will require the legal right to work in the location you are applying for

Company:

InstaDeep

Qualifications:

Language requirements:

Specific requirements:

Educational level:

Level of experience (years):

Senior (5+ years of experience)

Tagged as: Academia, Data Analysis, France, Machine Learning, NLP